Assessing Readiness of IP Networks to Support Desktop Videoconferencing Using OPNET

OPNET is a powerful network design and simulation tool that has gained popularity in industry and academia. However, there exists no known simulation approach on how to deploy a popular real-time network service such as videoconferencing. This paper demonstrates how OPNET can be leveraged to assess the readiness of existing IP networks to support desktop videoconference. To date, OPNET does not have built-in features to support videoconferencing or its deployment. The paper offers remarkable details on how to model and configure OPNET for such a purpose. The paper considers two types of video traffic (viz. fixed and empirical video packet sizes). Empirical video packet sizes are collected from well-known Internet traffic traces. The paper presents in-depth analysis and interpretation of simulation results and shows how to draw proper engineering conclusions

Assessing Readiness of IP Networks to Support Desktop Videoconferencing Using OPNET

OPNET is a powerful network design and simulation tool that has gained popularity in industry and academia. However, there exists no known simulation approach on how to deploy a popular real-time network service such as videoconferencing. This paper demonstrates how OPNET can be leveraged to assess the readiness of existing IP networks to support desktop videoconference. To date, OPNET does not have built-in features to support videoconferencing or its deployment. The paper offers remarkable details on how to model and configure OPNET for such a purpose. The paper considers two types of video traffic (viz. fixed and empirical video packet sizes). Empirical video packet sizes are collected from well-known Internet traffic traces. The paper presents in-depth analysis and interpretation of simulation results and shows how to draw proper engineering conclusions

Assessing Readiness of IP Networks to Support Desktop Videoconferencing Using OPNET

OPNET is a powerful network design and simulation tool that has gained popularity in industry and academia. However, there exists no known simulation approach on how to deploy a popular real-time network service such as videoconferencing. This paper demonstrates how OPNET can be leveraged to assess the readiness of existing IP networks to support desktop videoconference. To date, OPNET does not have built-in features to support videoconferencing or its deployment. The paper offers remarkable details on how to model and configure OPNET for such a purpose. The paper considers two types of video traffic (viz. fixed and empirical video packet sizes). Empirical video packet sizes are collected from well-known Internet traffic traces. The paper presents in-depth analysis and interpretation of simulation results and shows how to draw proper engineering conclusions

Comparison of equatorial plasma bubble zonal drifts and neutral winds velocity over Southeast Asia

The purpose of the presented study is to investigate the zonal drifts of Equatorial Plasma Bubbles (EPB) which applied two different ground-based instruments. Malaysia Real-Time Kinematics GNSS Network (MyRTKnet), consists more than 78 GPS receivers was used to observe EPB along 96° East to 120° East longitudes. Subsequently, zonal drift of EPBs derived from GPS-ROTI is compared with neutral winds velocity from Fabry-Perot interferometer (FPI). On 10 April 2013, we founded the maximum drift is about 194.4 m/s at 1430 UT to 1500 UT whereas the minimum drift is 111.1 m/s at 1330 UT to 1400 UT. The results illustrate that temporal variations of EPB zonal drift velocities are consistent with the neutral winds

Alcohol Use and its Associated Factors among Residents of an Urban Community in Plateau State Nigeria

Background:According to the World Health Organization (WHO), alcohol use contributes about 2.3 million deaths globally and accounts for 3.8% of global mortality. Nigeria ranks as the leading country in alcohol consumption in Africa. In view of this, this study was conducted to assess the level of alcohol use and its associated factors among residents of an urban community in Plateau state, Nigeria.Methodology: A cross sectional study carried outnbsp among 212 adult residents of AngwanRukuba community of Jos North Local Government Area of Plateau Statenbsp using quantitative method of data collection.nbsp Epi info statistical software version 7.0 was used for data analysis with adjusted odds ratio and 95% confidence intervalused in the study while a p-value of le 0.05 was considered statistically significant.Result: The average age of the respondents in this study was 28.2plusmn10.4 years with majority being 30 years and below. More of the respondents 142(60.8%) were current consumers of alcoholic drinks with harmful level of alcohol intake found to be 32.0%.Sex, quantity of drinks adjudged as normal in one sitting and age of onset of alcohol use were found to significantly predict harmful intake of alcohol containing drinks in the study.Conclusion: A relatively high level of alcohol use was found in this study with a corresponding level of harmful use. Sex, age of onset of alcohol use and quantity of drinks adjudged as normal in a sitting were significant contributors to harmful alcohol use.nbs

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk

Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria.

After the successful roll out of MenAfriVac, Nigeria has experienced sequential meningitis outbreaks attributed to meningococcus serogroup C (NmC). Zamfara State in North-western Nigeria recently was at the epicentre of the largest NmC outbreak in the 21st Century with 7,140 suspected meningitis cases and 553 deaths reported between December 2016 and May 2017. The overall attack rate was 155 per 100,000 population and children 5-14 years accounted for 47% (3,369/7,140) of suspected cases. The case fatality rate (CFR) among children 5-9 years was 10%, double that reported among adults ≥ 30 years (5%). NmC and pneumococcus accounted for 94% (172/184) and 5% (9/184) of the laboratory-confirmed cases, respectively. The sequenced NmC belonged to the ST-10217 clonal complex (CC). All serotyped pneumococci were PCV10 serotypes. The emergence of NmC ST-10217 CC outbreaks threatens the public health gains made by MenAfriVac, which calls for an urgent strategic action against meningitis outbreaks

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P = 9.2 x 10(-20)), ER-negative BC (P = 1.1 x 10(-13)), BRCA1-associated BC (P = 7.7 x 10(-16)) and triple negative BC (P-diff = 2 x 10(-5)). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P = 2 x 10(-3)) and ABHD8 (PPeer reviewe

The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century